Pipeline

KER-050 is an investigational activin receptor type IIA (ActRIIA) fusion protein designed to inhibit select TGF-β ligands, including activin A. Based on data from our completed Phase 1 clinical trial and multiple preclinical studies, we believe KER-050 has the potential to increase red blood cell and platelet production by acting across the spectrum of cellular differentiation and maturation in hematopoiesis while also improving bone health.

We are developing KER-050 for the treatment of ineffective hematopoiesis in myelodysplastic syndromes (MDS) and myelofibrosis (MF), where the impact of the disease in the bone marrow microenvironment can contribute to anemia, thrombocytopenia, neutropenia and an increased risk of acute myeloid leukemia. For more information about our ongoing Phase 2 clinical trials in MDS and MF, click here.

KER-047 is an investigational small molecule designed to potently and selectively inhibit activin receptor-like kinase-2 (ALK2). Excessive ALK2 signaling causes elevated levels of hepcidin, a key regulator of iron absorption and recycling. KER-047 is designed to block the signaling from ALK2 to normalize hepcidin expression and mobilize iron out of tissues. We believe this effect will result in increased iron bioavailability, potentially leading to a restoration of erythropoiesis and reduction in iron overload in patients with functional iron deficiency.

For more information about our Phase 2 clinical trial in Functional Iron Deficiency-Anemia in MDS and MF, click here.

KER-012 is an investigational modified activin receptor type IIB (ActRIIB) fusion protein being developed for the treatment of pulmonary arterial hypertension (PAH) and cardiovascular disorders. KER-012 is designed to normalize blood vessel thickness and heart function by inhibiting select TGF-β ligands, including activin A, activin B and myostatin (GDF8)—which stimulate smooth muscle hypertrophy and fibrosis—while sparing the bone morphogenic protein (BMP) ligands. For more information about our ongoing Phase 2 clinical trial in PAH, click here.

KER-065 is an investigational selective activin receptor ligand trap being developed for the treatment of neuromuscular disorders, with an initial focus on Duchenne muscular dystrophy (DMD). KER-065 is designed to act as a ligand trap and inhibit the biological effects of myostatin and activin A to increase skeletal muscle and bone mass, increase fat metabolism and reduce fibrosis.